Issue 21, 1989

Design and synthesis of an orally potent human renin inhibitor containing a novel amino acid, cyclohexylnorstatine

Abstract

An orally potent human renin inhibitor (1a) containing a novel amino acid, (2R,3S)-3-amino-4-cyclohexyl-2-hydroxybutyric acid named cyclohexylnorstatine, has been designed from the angiotensinogen transition-state and synthesized.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1989, 1678-1680

Design and synthesis of an orally potent human renin inhibitor containing a novel amino acid, cyclohexylnorstatine

K. Iizuka, T. Kamijo, H. Harada, K. Akahane, T. Kubota, H. Umeyama and Y. Kiso, J. Chem. Soc., Chem. Commun., 1989, 1678 DOI: 10.1039/C39890001678

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