Cycloaddition route to 14-hydroxymethyl-19-norprogesterone
Abstract
Diels–Alder reaction of 3-methoxy-16-methylestra-1,3,5(10),14,16-pentaen-17-yl acetate with phenyl vinyl sulphone affords three 14,17-cycloadducts, two of which are efficiently converted into 14-hydroxymethyl-19-norprogesterone.