Formation of a novel bicyclic γ-lactam with isopenicillin N synthase
Abstract
Incubation of isopenicillin N synthase (IPNS) with [(5S)-5-amino-5-carboxypentanoyl]-L- homocysteinyl-L-cysteine (14) resulted in the formation of a novel bicyclic γ-lactam (17) containing an intramolecular disulphide linkage.