Stereoselective synthesis of arylglycine derivatives using arene–manganese tricarbonyl complexes

Abstract

Arene–Mn(CO)₃ cations react with the Schöllkopf chiral glycine enolate equivalent (1) or (2) to give dienyl–Mn(CO)₃ complexes which are converted to arylglycine methyl esters; the reaction sequence can be performed on arene–Mn(CO)₃ complexes having protected amino acid substituents to give diaryl ethers having amino ester groups on both aromatic rings.