New insights into the mechanism of the cis-platin–guanosine 5′-monophosphate reaction
Abstract
The reaction of cis-diamminedichloroplatinum(II) and cis-dichloroethylenediamineplatinum(II) with guanosine 5′-monophosphate (GMP) proceed through the formation of a N-7-bound mono(GMP) complex which undergoes further reaction with the initial plantinum substrate and another GMP molecule to form a GMP-bridged diplatinum(II,II) species and a bis(GMP) complex.