Asymmetric synthesis of α,α-dichlorosulphoxides from substituted thioacetates and sodium hypochlorite in β-cyclodextrin complexes

Abstract

The reaction of β-cyclodextrin complexes of substituted thioacetates (1) with sodium hypochlorite in aqueous medium gives optically active α,α-dichlorosulphoxides (2) in good yields with an enantiomeric excess (e.e) of up to 53%.