Cultures of Nocardia mediterrance utilise atmospheric oxygen to form the C-1 oxygen function and C-29 vinyl ether group of the ansamycin antibiotics rifamycin B, O, and S, while the C-8 phenolic hydroxy group and C-8 carbon atom are both derived from the carboxy group of 3-amino-5-hydroxybenzoic acid; these results exclude 8-deoxyansamycins as possible biosynthetic intermediates.
M. G. Anderson, D. Monypenny, R. W. Rickards and J. M. Rothschild, J. Chem. Soc., Chem. Commun., 1989, 311 DOI: 10.1039/C39890000311
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