Simultaneous determination of tranylcypromine sulphate and trifluoperazine dihydrochloride in tablets by first- and fourth-derivative ultraviolet spectrophotometry

Abstract

A rapid and simple method for the simultaneous determination of trifluoperazine dihydrochloride and tranylcypromine sulphate by first- and fourth-derivative UV spectrophotometry is presented. The procedure consists of extraction in 0.1 M hydrochloric acid, filtration and measurement of the amplitudes of the first- and fourth-derivative spectra at 260 and 271 nm, respectively. A zero-crossing technique is used for the determination of trifluoperazine. Good linearity, accuracy, precision and selectivity were found, and the method is proposed for routine quality control purposes, even for the uniformity of contents test.