Equilibrium constants and assay of benzodiazepines in acetic acid

Abstract

The over-all dissociation constants, in anhydrous acetic acid, of a series of benzodiazepines have been determined. A method is described for evaluating the formation constants of the perchlorate salts. From these values simple potentiometric and visual titration methods for the assay of benzodiazepines in acetic acid are described.