Catalytic effects in aromatic nucleophilic substitution reactions. Reactions between 1-fluoro-2,4-dinitrobenzene and 2-aminothiazole derivatives

Abstract

The title reactions follow a second-order kinetic law in benzene and autocatalysis phenomena are not observed. The reactions are catalysed by 1,4-diaza[2.2.2]bicyclo-octane, α-pyridone, and δ-valerolactam. The kinetic data are consistent with the presence of an interaction between the substrate and the catalyst in the catalysed-reaction pathway.