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Issue 6, 1988
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Synthesis of analogues of 6β-bromopenicillanic acid and penicillanic acid S,S-dioxide. Part 1. Synthesis of 3α-derivatives of 6β-bromo-2,2-dimethylpenam and 2,2-dimethylpenam S,S-dioxide

Abstract

The synthesis of analogues of 6β-bromopenicillanic acid (1) and the sulphone of penicillanic acid (2), where the 3α-carboxyl group has been transformed into 3α-hydroxymethyl, fluoromethyl and cyano groups and the attempted transformation into a 3α-formyl group are described. These analogues showed no significant β-lactamase inhibitory activity against B. cereusβ-lactamase I.

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Article type: Paper
DOI: 10.1039/P19880001551
J. Chem. Soc., Perkin Trans. 1, 1988, 1551-1555

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    Synthesis of analogues of 6β-bromopenicillanic acid and penicillanic acid S,S-dioxide. Part 1. Synthesis of 3α-derivatives of 6β-bromo-2,2-dimethylpenam and 2,2-dimethylpenam S,S-dioxide

    E. G. Mata, E. L. Setti, O. A. Mascaretti, S. B. Boggio and O. A. Roveri, J. Chem. Soc., Perkin Trans. 1, 1988, 1551
    DOI: 10.1039/P19880001551

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