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Issue 4, 1988
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Sodium perfluoroalkane carboxylates as sources of perfluoroalkyl groups

Abstract

Sodium trifluoroacetate, in the presence of copper(I) iodide, is used as a source of trifluoromethyl to replace halogen by trifluoromethyl in benzenoid and heterocyclic aromatic systems, as well as in alkenyl and alkyl halogen compounds. The mechanism of this interesting copper-assisted process has been explored and an intermediate of the form [CF3Cul] is proposed. Introduction of higher perfluoroalkyl groups from their respective sodium perfluoroalkane carboxylates has been demonstrated and the mechanistic features are compared with those of the trifluoromethylation process.

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Article information


J. Chem. Soc., Perkin Trans. 1, 1988, 921-926
Article type
Paper

Sodium perfluoroalkane carboxylates as sources of perfluoroalkyl groups

G. E. Carr, R. D. Chambers, T. F. Holmes and D. G. Parker, J. Chem. Soc., Perkin Trans. 1, 1988, 921
DOI: 10.1039/P19880000921

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