Metabolites of the higher fungi. Part 23. The punctaporonins. Novel bi-, tri-, and tetra-cyclic sesquiterpenes related to caryophyllene, from the fungus Poronia punctata(Linnaeus:Fries) Fries

Abstract

Six new sesquiterpenes have been isolated from the culture medium of the fungus Poronia punctata. Punctaporonins A, D, E, and F are isomeric allylic alcohols possessing a tricyclic carbon skeleton not previously found in nature. Punctaporonin B is a related trihydroxycaryophyllene isomer, and punctaporonin C is a novel tetracyclic hemisuccinate. An additional major metabolite has been identified as (E)-methyl 3-(4-methoxyphenoxy)propenoate.