Suitably functionalised pyrimidine-2,4-diones (1) cyclised intramolecularly to yield the novel furo[2″,3″:4′,5′]isoxazolo[3′,4′:4,5]pyrido[2,3-d]pyrimidines (5) and (9) in excellent yields. Remarkably, the pyrimidone nucleus was unaffected nor were there any side-reactions in this synthesis.
D. Prajapati, P. Bhuyan and J. S. Sandhu, J. Chem. Soc., Perkin Trans. 1, 1988, 607 DOI: 10.1039/P19880000607
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