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Issue 3, 1988
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An efficient synthesis of (±)-latifine dimethyl ether

Abstract

4,5-Dimethoxy-3-(4′-methoxyphenyl)phthalide (2) was hydrogenolysed to give 3,4-dimethoxy-2-(4′-methoxybenzyl)benzoic acid (3). The N-methylamide of (3) was lithiated and treated with dimethylformamide to furnish 3,4-dihydro-3-hydroxy-5,6-dimethoxy-4-(4′-methoxyphenyl)-2-methylisoquinolin-1(2H)-one (5). Reduction of compound (5) with lithium aluminium hydride gave (±)-latifine dimethyl ether (7).

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Article type: Paper
DOI: 10.1039/P19880000481
J. Chem. Soc., Perkin Trans. 1, 1988, 481-483

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    An efficient synthesis of (±)-latifine dimethyl ether

    V. G. Gore and N. S. Narasimhan, J. Chem. Soc., Perkin Trans. 1, 1988, 481
    DOI: 10.1039/P19880000481

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