Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 3, 1988
Previous Article Next Article

Asymmetric syntheses. Part 2. Reduction of ketones with chiral sodium borohydride-lactic acid derivative systems

Abstract

Asymmetric reduction of acetophenone, propiophenone, and 2-acetylnaphthalene using chirally modified reagents prepared from sodium borohydride and optically active (S)-lactic acid derivatives produced the corresponding optically active (R) alcohols with enantiomeric excesses as high as 38.3%. The extent of asymmetric synthesis was dependent on the catalyst, the solvent, and the reaction conditions. 1H and 13C N.m.r. data for sodium borohydride chiral species are reported.

Back to tab navigation

Article information


J. Chem. Soc., Perkin Trans. 1, 1988, 417-422
Article type
Paper

Asymmetric syntheses. Part 2. Reduction of ketones with chiral sodium borohydride-lactic acid derivative systems

G. Bianchi, F. Achilli, A. Gamba and D. Vercesi, J. Chem. Soc., Perkin Trans. 1, 1988, 417
DOI: 10.1039/P19880000417

Search articles by author

Spotlight

Advertisements