Issue 16, 1988
From the journal:

Journal of the Chemical Society, Chemical Communications

Biosynthesis of vitamin B12: when is the 12β-methyl group of the vitamin generated by acetate decarboxylation?

Francis Blanche,   Sheetal Handa,   Denis Thibaut,   Colin L. Gibson,   Finian J. Leeper  and  Alan R. Battersby  

Abstract

The 12-methyl analogue (13) of the aromatised form of precorrin-3(5) has been prepared by enzymic C-methylation of 12-decarboxy-uro'gen-III (2) and is used for incorporation experiments which indicate that decarboxylation of the 12-acetate residue in B12-biosynthesis occurs after C-17 methylation.

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Article information

DOI
https://doi.org/10.1039/C39880001117
Article type
Paper

J. Chem. Soc., Chem. Commun., 1988, 1117-1119

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Biosynthesis of vitamin B12: when is the 12β-methyl group of the vitamin generated by acetate decarboxylation?

F. Blanche, S. Handa, D. Thibaut, C. L. Gibson, F. J. Leeper and A. R. Battersby, J. Chem. Soc., Chem. Commun., 1988, 1117 DOI: 10.1039/C39880001117

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