Issue 15, 1988

The synthesis and DNA footprinting of acridine-linked netropsin and distamycin bifunctional mixed ligands

Abstract

The new synthetic acridine-linked netropsins (9a–c) and distamycin (10a–c) are bifunctional mixed ligands which bind to DNA by both intercalation and minor-groove association and show enhanced preference for A–T rich sites.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1988, 1049-1052

The synthesis and DNA footprinting of acridine-linked netropsin and distamycin bifunctional mixed ligands

A. Eliadis, D. R. Phillips, J. A. Reiss and A. Skorobogaty, J. Chem. Soc., Chem. Commun., 1988, 1049 DOI: 10.1039/C39880001049

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