2′-Deoxy-2′-fluoro-ara-aristeromycin, a new anti-herpes agent: the first direct introduction of a 2′-fluoro substituent into a carbocyclic nucleoside

Keith Biggadike; Alan D. Borthwick; Anne M. Exall; Barrie E. Kirk; Richard A. Ward

doi:10.1039/C39880000898

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2′-Deoxy-2′-fluoro-ara-aristeromycin, a new anti-herpes agent: the first direct introduction of a 2′-fluoro substituent into a carbocyclic nucleoside

Keith Biggadike, Alan D. Borthwick, Anne M. Exall, Barrie E. Kirk and Richard A. Ward

Abstract

Aristeromycin has been converted in four stages into its 2′-deoxy-2′-fluoro-ara-analogue (4); compound (4) displayed potent anti-herpes activity both in vitro and in vivo.

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DOI: https://doi.org/10.1039/C39880000898
Article type: Paper

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J. Chem. Soc., Chem. Commun., 1988, 898-900

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2′-Deoxy-2′-fluoro-ara-aristeromycin, a new anti-herpes agent: the first direct introduction of a 2′-fluoro substituent into a carbocyclic nucleoside

K. Biggadike, A. D. Borthwick, A. M. Exall, B. E. Kirk and R. A. Ward, J. Chem. Soc., Chem. Commun., 1988, 898 DOI: 10.1039/C39880000898

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Journal of the Chemical Society, Chemical Communications

2′-Deoxy-2′-fluoro-ara-aristeromycin, a new anti-herpes agent: the first direct introduction of a 2′-fluoro substituent into a carbocyclic nucleoside

Abstract

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2′-Deoxy-2′-fluoro-ara-aristeromycin, a new anti-herpes agent: the first direct introduction of a 2′-fluoro substituent into a carbocyclic nucleoside

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