Aspects of molecular recognition: use of a truncated driven pseudo-NOESY experiment to elucidate the environment of intermolecular electrostatic interactions in vancomycin

Abstract

The folding-in of a hydrophobic sidechain, to complete a wall of a peptide carboxylate anion binding pocket, in the vancomycin–di-N-acetyl-L-Lys-D-Ala-D-Ala complex has been unambiguously determined using a series of nuclear Overhauser effect difference spectra, presented as a two-dimensional contour plot.