The efficient synthesis of a complex O-phosphoseryl-containing peptide Ac-Glu-PSer-Leu-PSer-P-Ser-PSer-Glu-Glu-NHMe
Abstract
The title octapeptide was prepared by the synthesis of the fully protected tetra-Ser(PO3Ph2)-octapeptide by incorporation of Boc-Ser(PO3Ph2)-OH (Boc = t-butoxycarbonyl) in conventional Boc/solution phase peptide synthesis, followed by the complete hydrogenolytic cleavage of the phenyl groups from the Ser(PO3Ph2)-octapeptide.