Issue 10, 1988

The efficient synthesis of a complex O-phosphoseryl-containing peptide Ac-Glu-PSer-Leu-PSer-P-Ser-PSer-Glu-Glu-NHMe

Abstract

The title octapeptide was prepared by the synthesis of the fully protected tetra-Ser(PO3Ph2)-octapeptide by incorporation of Boc-Ser(PO3Ph2)-OH (Boc = t-butoxycarbonyl) in conventional Boc/solution phase peptide synthesis, followed by the complete hydrogenolytic cleavage of the phenyl groups from the Ser(PO3Ph2)-octapeptide.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1988, 664-666

The efficient synthesis of a complex O-phosphoseryl-containing peptide Ac-Glu-PSer-Leu-PSer-P-Ser-PSer-Glu-Glu-NHMe

J. W. Perich and R. B. Johns, J. Chem. Soc., Chem. Commun., 1988, 664 DOI: 10.1039/C39880000664

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