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Issue 10, 1988
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Synthesis and enzymatic resolution of carbocyclic 2′-ara-fluoro-guanosine: a potent new anti-herpetic agent

Abstract

(±)-Carbocyclic-9-(2′-deoxy-2′-β-fluoroarabinofuranosyl) guanine (8) and the corresponding furanose compound (12) have been synthesised; the former compound [which was resolved by formation of the monophosphate (20) and enantioselective hydrolysis using a 5′-nucleotidase] is an extremely potent inhibitor of herpes simplex viruses types 1 and 2.

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Article type: Paper
DOI: 10.1039/C39880000656
Citation: J. Chem. Soc., Chem. Commun., 1988,0, 656-658
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    Synthesis and enzymatic resolution of carbocyclic 2′-ara-fluoro-guanosine: a potent new anti-herpetic agent

    A. D. Borthwick, S. Butt, K. Biggadike, A. M. Exall, S. M. Roberts, P. M. Youds, B. E. Kirk, B. R. Booth, J. M. Cameron, S. W. Cox, C. L. P. Marr and M. D. Shill, J. Chem. Soc., Chem. Commun., 1988, 0, 656
    DOI: 10.1039/C39880000656

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