Coprinolone, an oxygen-bridged protoilludane from the fungus Coprinus psychromorbidus: structure determination by chemical and n.m.r. studies aided by biosynthetic incorporation of [1,2-13C2]acetate

Abstract

The structure of a sesquiterpene ketol, coprinolone, from the W2 isolate of the fungus Coprinus psychromorbidus, has been deduced as (1a) by chemical transformations and from ¹H and ¹³C n.m.r. data; confirmation was obtained from the labelling pattern of the compound from cultures supplemented with [1,2-¹³C₂]acetate.