δ-Lactams: synthesis from D-glucose, and preliminiary evaluation as a fucosidase inhibitor, of L-fuconic-δ-lactam
Abstract
Polyhydroxylated δ-lactams are a potential class of glycosidase inhibitors; the synthesis of L-fuconic-δ-lactam (7), which preliminary studies have shown to be a weak but specific α-L-fucosidase inhibitor, is described.