Chiral discrimination towards racemic alcohols through Host/Guest clathrate inclusion with axially chiral 1,1′-binaphthyl-2,2′-dicarboxylic acid

Abstract

Axially chiral 1,1′-binaphthyl-2,2′-dicarboxylic acid (1) was successfully utilised as a new type of chiral host molecule soluble in aqueous alkaline solution; 1-phenylalkan-1-ols were optically resolved by means of chiral host/guest clathrate inclusion giving optical purities ranging from 18 to 90% enantiomeric excess (e.e.), depending on the alkyl group.