A series of novel 7-spiro-epoxycephalosporins prepared by the reaction of oxalyl halides with 7-diazocephalosporanate followed by various nucleophiles is reported: some of these compounds exhibit notable antibacterial activity which is dependent on the substituents and stereochemistry of the epoxide.
B. W. Bycroft, R. E. Shute and M. J. Begley, J. Chem. Soc., Chem. Commun., 1988, 276 DOI: 10.1039/C39880000276
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