Chiral 2,2-disubstituted cyclohexanones; annulation via Claisen rearrangement products
Abstract
The methyl enol ether of 2-methylcyclohexanone reacts regiospecifically and enantioselectively with (R)- and (S)-but-3-en-2-ol to give respectively, the (R)- and (S)- forms of 2-methyl-2-(trans-but-2-enyl)cyclohexanone.