Determination of methanesulphonyl fluoride in blood matrix with a fluoride ion-selective electrode

Abstract

Methanesulphonyl fluoride (MSF) has been determined in blood matrix by measuring the fluoride ion activity with a fluoride ion-selective electrode after a quantitative transformation reaction between MSF and isopropanol in basic aqueous solution. It was found that the blood matrix did not affect the conversion of MSF into fluoride ion nor did it interfere with the detection of fluoride ion by the electrode. The detection limit is at least 0.1 p.p.m. of MSF under normal conditions, which is adequate for clinical applications, with a therapeutic range of 0.12–10.0 p.p.m.