Issue 7, 1988

Direct 1H NMR determination of the enantiomeric excess of carnitine

Abstract

The enantiomeric purity of carnitine may be determined without any derivatisation of the molecule. Preparations of aqueous mixtures containing stereochemically pure L-malic acid, carnitine and europium trichloride lead to the formation of a complex in which the trimethylammonium groups of D- and L-carnitine are diastereotopic. The resolution is observed only when strict experimental conditions are maintained.

Article information

Article type
Paper

Analyst, 1988,113, 1143-1144

Direct 1H NMR determination of the enantiomeric excess of carnitine

J. Bounoure and J. Souppe, Analyst, 1988, 113, 1143 DOI: 10.1039/AN9881301143

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