Differential-pulse adsorptive stripping voltammetry of the psychotropic drugs triazolam and clotiazepam

Abstract

The surface-active properties of the psychotropic drugs triazolam and clotiazepam at a hanging mercury drop electrode allow their sensitive determination by differential-pulse adsorptive stripping voltammetry. The adsorptive stripping response has been evaluated with respect to accumulation time, accumulation potential, concentration dependence, electrolyte and pH. Determination limits are 6 × 10^–10M for triazolam and clotiazepam with accumulation times of 4 and 10 min, respectively. Coefficients of variation at the 1 × 10^–8M levels (six determinations) were typically <1.5%.