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Issue 0, 1987
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Studies on fungal products. Part 13. Isolation and structures of dithiosilvatin and silvathione, novel dioxopiperazine derivatives from Aspergillus silvaticus

Abstract

Dithiosilvatin (1), an epidithiodioxopiperazine, and silvathione (2), a dioxopiperazinethione, were isolated from Aspergillus silvaticus. Their structures were established on the basis of chemical reactions and spectroscopic evidence. Dithiosilvatin (1) is a very rare example of naturally occurring epidithiodioxopiperazines, a class of compounds which appear to be biosynthesized originally from glycine, and phenylalanine or tyrosine. Silvathione (2) is the second example of a natural dioxopiperazinethione and is biogenetically a possible key intermediate in the formation of trioxopiperazine from epidithiodioxopiperazine.

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Article type: Paper
DOI: 10.1039/P19870002099
J. Chem. Soc., Perkin Trans. 1, 1987, 2099-2101

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    Studies on fungal products. Part 13. Isolation and structures of dithiosilvatin and silvathione, novel dioxopiperazine derivatives from Aspergillus silvaticus

    N. Kawahara, K. Nozawa, S. Nakajima and K. Kawai, J. Chem. Soc., Perkin Trans. 1, 1987, 2099
    DOI: 10.1039/P19870002099

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