1 H- and 13C-N.m.r. spectroscopy have been used to show that in aqueous solution at physiological pH the antibiotic citrinin exists not as the quinone methide (1) but as a diastereoisomeric mixture of hydrates. The equilibrium between the two diastereoisomers is slow, suggesting that citrinin, which is believed to interact with deoxyribonucleic acid (DNA), does not act as a simple Michael acceptor in vivo. Neither does citrinin intercalate into DNA.
J. Barber, J. L. Cornford, T. D. Howard and D. Sharplese, J. Chem. Soc., Perkin Trans. 1, 1987, 2743 DOI: 10.1039/P19870002743
To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.
If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.
If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.
Read more about how to correctly acknowledge RSC content.
Please wait while we load your content...