We report efficient syntheses of 2-bromo- and 2-chloro-3-methoxycyclohex-2-enone and their use as m-hydroxyphenyl cation synthons for the α-arylation of lactams. The sequence has been used to synthesize the analgesic drug meptazinol.
R. G. Shepherd and A. C. White, J. Chem. Soc., Perkin Trans. 1, 1987, 2153 DOI: 10.1039/P19870002153
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