Asymmetric conjugate addition to unsaturated chiral amido alcohols using Grignard reagents co-ordinated with tertiary amines or DBU. Preparation of optically active 3-substituted carboxylic acids and (S)-(–)-citronellol
Abstract
Optically active 3-substituted carboxylic acids and (S)-(–)-citronellol have been obtained by diastereoselective conjugate addition of Grignard reagents co-ordinated with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) to chiral amido alcohols derived from (S)-proline.