The synthesis of aromatic leukotriene analogues; regioselective trapping of 2,4′-dilithiophenylethyne

Abstract

The 8,11 -bridged aromatic leukotriene B₄ analogues (3), (4), and (5), in which conformational freedom is restricted, have been prepared by extremely short synthetic routes. Conditions are described which allow the regioselective electrophililic trapping of 2,4′-dilithiophenylethyne at the 4′-site. The application of this methodology to the preparation of LTB₄ analogues (3) and (4) is discussed.