18-Substituted steroids. Part 12. Synthesis of aldosterone 21-sulphate, and an improved general procedure for preparing steroid sulphates

Abstract

Treatment of aldosterone with triethylamine–sulphur trioxide in pyridine followed by a convenient purification procedure involved absorption on a C₁₈‘Sep-pak’ was found to give aldosterone 21-sulphate. The product was characterised by its 400 MHz ¹H n.m.r. spectrum, which showed the presence of four isomeric forms. The improved sulphation and purification procedure has been extended to the preparation of some other steroid sulphates.