The synthesis and resolution of potential appetite suppressant 3-(2-aryloxyethyl)morpholines is described. Assignment of the absolute configuration of the resolved enantiomers is based on a chiral synthesis from O-phenylhomoserines of known configuration. Appetite suppressant effects in dogs are briefly reported.
G. R. Brown, A. J. Foubister and D. Stribling, J. Chem. Soc., Perkin Trans. 1, 1987, 547 DOI: 10.1039/P19870000547
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