Enantioselective aldol reactions using chiral lithium amides as a chiral auxiliary
Abstract
The enantioselective aldol reaction of ethyl t-butyl ketone with benzaldehyde in the presence of chiral ligands has been thoroughly investigated. With the lithium amide derived from 2-isopropylamino-1-methoxy-3-methylbutane (3c) as chiral ligand, a chemical yield of 93% and 68% enantiomeric excess were realized.