(R;E)-3,3,3-Trifluoroprop-1-enyl p-tolyl sulphoxide, prepared in three steps from ethyl trifluoroacetate, showed a high degree of diastereoselectivity in Michael addition reactions with enolates; by this means, optically active trifluoromethylated organic molecules can be obtained readily in high yield as well as in high optical purity.
T. Yamazaki, N. Ishikawa, H. Iwatsubo and T. Kitazume, J. Chem. Soc., Chem. Commun., 1987, 1340 DOI: 10.1039/C39870001340
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