SCHEDULED MAINTENANCE
An enantiospecific synthesis of (–)-α-kainic acid (1) from L-aspartic acid (7) has been achieved in which the C-3 to C-4 bond is formed by a stereocontrolled enolate Claisen rearrangement [(13)→(14)] which delivers the correct geometry at the C-3 and C-4 asymmetric centres.
J. Cooper, D. W. Knight and P. T. Gallagher, J. Chem. Soc., Chem. Commun., 1987, 1220 DOI: 10.1039/C39870001220
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