Issue 11, 1987

An effective substitute for α-aminoadipic acid in the enzymatic synthesis of penicillins

Abstract

meta-Carboxyphenylacetylcysteinylvaline has been demonstrated to be a highly efficient substrate for the enzyme isopenicillin N synthetase with similar Michaelis constants and maximum velocity parameters to the natural substrate δ-(L-α-aminoadipoyl)-L-cysteinyl-D-valine.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1987, 806-807

An effective substitute for α-aminoadipic acid in the enzymatic synthesis of penicillins

J. E. Baldwin, R. M. Adlington, M. J. C. Crabbe, G. C. Knight, T. Nomoto and C. J. Schofield, J. Chem. Soc., Chem. Commun., 1987, 806 DOI: 10.1039/C39870000806

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