Trimethylsilyl trifluoromethanesulphonate as a useful deprotecting reagent in both solution and solid phase peptide syntheses

Abstract

Trimethylsilyl trifluoromethanesulphonate in trifluoroacetic and has been found to cleave, in the presence of thioanisole, a number of protecting groups currently employed in peptide synthesis, without significant side reactions and with a much faster rate of reaction than trifluoromethanesulphonic acid in trifluoroacetic acid; this new deprotecting reagent has geen used in solution and solid phase peptide syntheses of nueromedin U-25 (a 25-residue peptide) and a rabit stomach peptide (an 8-residue peptide), respectively.