The diastereoisomeric 10-(epoxyethyl)estr-4-ene-3,17-diones (2) and (3) have been synthesized, their conformations and configurations have been established by X-ray crystallographic analysis, and they have been shown to be powerful inhibitors of human placental aromatase.
M. Shih, M. H. Carrell, H. L. Carrell, C. L. Wright, J. O. Johnston and C. H. Robinson, J. Chem. Soc., Chem. Commun., 1987, 213 DOI: 10.1039/C39870000213
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