A stereoselective synthesis of 1α-hydroxyvitamin D3(16) was achieved through the solvolysis of the 3,5-cyclovitamin D3(14) which was prepared from (–)-(1R,3S,5S)-3-methoxymethoxy-2-methylene-bicyclo[3.1.0]hexanecarbaldehyde (13) and 8-bromomethylenedes-AB-cholestane (1).
H. Nemoto, T. Kimura, H. Kurobe, K. Fukumoto and T. Kametani, J. Chem. Soc., Perkin Trans. 1, 1986, 1777 DOI: 10.1039/P19860001777
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