SCHEDULED MAINTENANCE
A new synthesis of 1,2,3,4,5,6-hexahydro-1,5-methano-2-benzazocines (7,8-benzomorphans) based on the acid-catalysed cyclization of 2-arylpiperidine-4-carboxylic acids is reported. The required carboxylic acids were prepared from 2-aryl-4-piperidones, by reaction with tosylmethyl isocyanide followed by hydrolysis of the resulting 4-cyanopiperidines.
J. Bosch, M. Rubiralta, M. Moral and J. Ariño, J. Chem. Soc., Perkin Trans. 1, 1986, 1533 DOI: 10.1039/P19860001533
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