The total synthesis of 18,18,18-trifluoro-17β-estradiol and related steroids is described, following the Torgov route. Some of these compounds show significant biological activity.
J. Blazejewski, R. Dorme and C. Wakselman, J. Chem. Soc., Perkin Trans. 1, 1986, 337 DOI: 10.1039/P19860000337
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