Notes. Complexation of gold(I) thiomalate (‘myocrisin’) with 1,3-diazinane-2-thione in aqueous solution followed by 13C nuclear magnetic resonance spectroscopy

Abstract

The interaction of gold(I) thiomalate (‘Myocrisin’; an anti-arthritic drug)[Au(tm)] with 1,3-diazinane-2-thione (L) has been studied in aqueous solution at pH * 7.2 by using ¹³C n.m.r. spectroscopy. It is found that [Au(tm)] forms a 1:1 complex of tm–Au–L. In the presence of excess thiomalate, L is displaced as a free ligand in solution suggesting that a thiol binds to gold(I) more strongly than does a thione.