A 2H and 13C n.m.r. study of the biosynthesis of the polyketide isocoumarin residue of canescin in Aspergillus malignus from [1,2-13C2]-, and [1-13C, 2-2H3]acetates, [Me-13C, 2H3]methionine, 6,8-dihydroxy-3,7-dimethylisocoumarin, and 6,8-dihydroxy-7-formyl-3-methylisocoumarin
Abstract
Evidence is presented that 6,8-dihydroxy-3,7-dimethylisocoumarin (8) and 6,8-dihydroxy-7-formyl-3-methylisocoumarin (9) are advanced precursors of the polyketide residue of canescin in Aspergillus malignus.