Eliminative ring fission of 1,2,4-trioxan-5-ones. A new approach to α-keto acids
Abstract
6-Mono-R-substituted 1,2,4-trioxan-5-ones readily undergo base-catalysed O–O bond cleavage to furnish α-keto acids (RCOCOOH) in high yields even when the R-substituents are bulky.