Reaction of bis(trimethylsilyl)formamide with simple aldehydes gives 1-formamido-1-trimethylsilyloxyalkanes (and the corresponding adducts with ketones), which undergo displacement of trimethylsilanol by a variety of nucleophiles to give α-substituted amides.
A. P. Johnson, R. W. A. Luke and R. W. Steele, J. Chem. Soc., Chem. Commun., 1986, 1658 DOI: 10.1039/C39860001658
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